DEN1A

BT-AP02218

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human DEN1A

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family| such as DENND1A| function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus| connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson| 2010

Human: Q8TEH3; Mouse: Q8K382;

110990

Human: 57706; Mouse: 227801

DEN1A

Neuroscience; Signal transduction

DENND1A