DUS7

BT-AP09372

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human DUS7

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs| designated MKPs| that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795)| JNK (see MIM 601158)| and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes| including cellular proliferation| apoptosis| differentiation| and stress responses (summary by Patterson et al.| 2009

Human: Q16829; Mouse: Q91Z46; Rat: Q63340;

46090

Human: 1849; Mouse: 235584

DUS7

Cell biology; Epigenetics and nuclear signaling

DUSP7