HYOU1

BT-AP10525

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human HYOU1

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction| resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis| it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors| especially in breast tumors| and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site| resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein| which is only 3 amino acids shorter than the mature protein in the ER| is thought to have a housekeeping function in the cytosol. In rat| this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.

Human: Q9Y4L1; Mouse: Q9JKR6; Rat: Q63617;

109890

Human: 10525; Mouse: 12282; Rat: 192235

HYOU1

Cancer; Cardiovascular; Epigenetics and nuclear signaling; Metabolism; Neuroscience; Signal transduction

HYOU1