IMPA1

BT-AP10613

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human IMPA1

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol| a precursor of phosphatidylinositol| and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1|4|5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1|3-diphosphate| myo-inositol-1|4-diphosphate| scyllo-inositol-phosphate| glucose-1-phosphate| glucose-6-phosphate| fructose-1-phosphate| beta-glycerophosphate| and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Human: P29218; Mouse: O55023; Rat: P97697;

30470

Human: 3612; Rat: 83523

IMPA1

Neuroscience; Metabolism; Signal transduction

IMPA1