RFX5

BT-AP04449

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human RFX5

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency| or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B| C| and D all lead to a deficiency in RFX| a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al.| 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

Human: P48382; Mouse: Q9JL61;

67760

Human: 5993; Mouse: 53970

RFX5

Epigenetics and nuclear signaling; Immunology

RFX5