Probable DNA dC->dU-editing enzyme APOBEC-3A

BT-AP05897

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 80-160

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster| thought to result from gene duplication| on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity| by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines| which leads to DNA degradation. However| other mechanisms are also thought to be involved| as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

Human: P31941;

Human: 100913187

Probable DNA dC->dU-editing enzyme APOBEC-3A ;EC 3.5.4.-;Phorbolin-1

Cell biology; Metabolism; Signal transduction

APOBEC3A