Bcl-2-like protein 1

BT-AP14436

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Recombinant Protein of Bcl-Xl

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Human: Q07817; Mouse: Q64373; Rat: P53563;

Human: 598

Bcl-2-like protein 1 ;Bcl2-L-1;Apoptosis regulator Bcl-X; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X

Cell biology; Cancer; Metabolism; Signal transduction

BCL2L1