Dual specificity protein phosphatase 6

BT-AP15337

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthetic Peptide of DUSP6

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t

Human: Q16828; Mouse: Q9DBB1; Rat: Q64346;

Human: 1848

Dual specificity protein phosphatase 6 ;EC 3.1.3.16;EC 3.1.3.48;Dual specificity protein phosphatase PYST1;Mitogen-activated protein kinase phosphatase 3;MAP kinase phosphatase 3;MKP-3; DUSP6; MKP3; PYST1; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3

Neuroscience

DUSP6