Full product name
TFIIH basal transcription factor complex helicase XPD subunit
Code
BT-AP15452
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Uniprot accession
Gene ID
Human: 2068
Synonyms
TFIIH basal transcription factor complex helicase XPD subunit ;EC 3.6.4.12;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein com
Research area
Epigenetics and nuclear signaling
Target protein
ERCC2
