Insulin [Cleaved into: Insulin B chain; Insulin A chain]

BT-AP10406

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthetic peptide from human protein at AA range: 30-70

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Human: P01308;

Human: 3630; Mouse: 0

Insulin [Cleaved into: Insulin B chain; Insulin A chain]; Insulin [Cleaved into: Insulin B chain; Insulin A chain;

Signal transduction; Cardiovascular; Metabolism; Neuroscience; Cancer

INS