Signal transducer and activator of transcription 4

BT-AP14541

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human Stat4 around the non-phosphorylation site of Y693.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

-20°C for 1 year

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Human: Q14765; Mouse: P42228;

Human: 6775

Signal transducer and activator of transcription 4; STAT4; Signal transducer and activator of transcription 4

Epigenetics and nuclear signaling; Cancer; Signal transduction

STAT4