Code
BT-MCA3394
Host
Mouse
Isotype
Mouse IgG1
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human BMP4 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
Uniprot accession
Molecular weight
64kDa
Gene ID
652
Synonyms
ZYME;BMP2B;OFC11;BMP2B1;MCOPS6;BMP4
Research area
Cancer,Stem cells,Cardiovascular,Signal transduction,Developmental biology
Target protein
BMP4
