Cortactin (Acetyl Lys235) Antibody

BT-AP02136

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. Cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. The aberrant regulation of CTTN contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for CTTN.

Human: Q14247; Mouse: Q60598;

61636

Human: 2017; Mouse: 13043

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Signal Transduction

CTTN