MYSM1 Antibody

BT-AP05743

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

MYSM1 (Myb Like, SWIRM And MPN Domains 1) is a Protein Coding gene. Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Diseases associated with MYSM1 include hemorrhagic cystitis. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein complex binding. An important paralog of this gene is MPND.

Human: Q5VVJ2; Mouse: Q69Z66;

95032

Human: 114803

MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1

Epigenetics and Nuclear Signaling

MYSM1