Rad50 Antibody

BT-AP07606

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

The antiserum was produced against synthesized peptide derived from human RAD50. AA range:681-730

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

RAD50 double strand break repair protein encoded by RAD50 is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. RAD50 double strand break repair protein forms a complex with MRE11 and NBS1. RAD50 double strand break repair protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. RAD50 double strand break repair protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest RAD50 is essential for cell growth and viability. Mutations in RAD50 are the cause of Nijmegen breakage syndrome-like disorder.

Human: Q92878; Mouse: P70388; Rat: Q9JIL8;

153892

Human: 10111; Rat: 64012

RAD50; DNA repair protein RAD50; hRAD50

Epigenetics and Nuclear Signaling

RAD50