Microtubule Associated Protein Tau

E1191Ra

Sandwich

48T,96T

2.56ng/L

5-1500ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

78,564

29477

MAPt;Microtubule-associated protein tau;Mtapt;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;pTau;RNPTAU;Tau;

Mapt

Neuroscience

MAPt