Alpha-Synuclein

E1401Mo

Sandwich

48T,96T

0.028ng/ml

0.05-30ng/ml

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).

14,485

20617

al;alp;alphaSYN;alpha-Syn;Alpha-synuclein;NACP;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;PARK4;SNCA;SYN

Snca

Neuroscience

SNCA