Rho-related GTP-binding protein RhoB(RHOB)

E1609Hu

Sandwich

48T,96T

6.68ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

22,123

388

ARH6;ARHB;h6;MST081;MSTP081;Rho cDNA clone 6;RHOB;RHOH6;Rho-related GTP-binding protein RhoB;

RHOB

Signal Transduction

RHOB