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Home > Product > ELISA Kit > Rat Advanced Glycosylation End Product-specific Receptor, AGER ELISA Kit

Rat Advanced Glycosylation End Product-specific Receptor, AGER ELISA Kit

Rat Advanced Glycosylation End Product-specific Receptor, AGER ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 9.14ng/L

Detection range: 20-4500ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Rat

Product Summary

Size: 48T,96T

Sensitivity: 9.14ng/L

Detection range: 20-4500ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Rat

Product overview

Full product name

Advanced glycosylation end product-specific receptor

Code

E1851Ra

Assay type

Sandwich

Size

48T,96T

Sensitivity

9.14ng/L

Detection range

20-4500ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Rat

Storage

2-8ºC

Assay time

1h 30m

Background

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UniProt accession

MASS(Da)

42,664

GeneID

81722

Synonyms

Advanced glycosylation end product-specific receptor;AGER;RAGE;Receptor for advanced glycosylation end products

Gene names

Ager

Research area

Neuroscience

Target protein

AGER

Components

Components Quantity
Pre-coated ELISA plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E1851Ra are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
2400ng/L 2.17 2.2 2.166
2.231
1200ng/L 1.249 1.208 1.174
1.167
600ng/L 0.761 0.795 0.76
0.828
300ng/L 0.391 0.403 0.368
0.414
150ng/L 0.251 0.216 0.182
0.182
0ng/L 0.04 0.034 0
0.029

Precision

We measured random samples of E1851Ra within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 836.18 45.96 5.5
Intra-Assay 2 18 1868.95 70.21 3.76
Intra-Assay 3 18 256.17 10.83 4.23

Protocols

References

Customer reviews and Q&As

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  • Size

    Code

    Price

  • 48T

    E1851Ra

    $320.00

  • 96T

    E1851Ra

    $458.00

Add to Cart

Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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