Disintegrin and metalloproteinase domain-containing protein 17

E2026Mo

Sandwich

48T,96T

5.23ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882063). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity).

93,056

11491

ADAM 17;ADAM17;CD antigen CD156b;CD156b;Disintegrin and metalloproteinase domain-containing protein 17;Tac;Tace;TNF-alpha convertase;TNF-alpha-converting enzyme;

Adam17

Cell Biology

ADAM17