Fructose-bisphosphate aldolase B

E2080Mo

Sandwich

48T,96T

0.155ng/mL

0.3-90ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP.

39,507

230163

Al;Ald;Aldo2;Aldo-2;ALDOB;Aldolase 2;BC016435;Fructose-bisphosphate aldolase B;Liver-type aldolase;

Aldob

Signal Transduction

ALDOB