Glutamate,NMDA receptor subunit epsilon-3

E2102Mo

Sandwich

48T,96T

4.45ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:1377365). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:8987814).

135,420

14813

GluN2C;Glutamate [NMDA] receptor subunit epsilon-3;Glutamate receptor ionotropic, NMDA 2C;GRIN2C;NMDA;NMDAR2C;N-methyl D-aspartate receptor subtype 2C;NR;NR2C;

Grin2c

Neuroscience

GRIN2C