Hepatocyte growth factor-regulated tyrosine kinase substrate

E2131Mo

Sandwich

48T,96T

9.75ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

86,015

15239

Hepatocyte growth factor-regulated tyrosine kinase substrate;Hgr;HGS;Hrs;tn;ZFYVE8

Hgs

Cell Biology

HGS