Runt-related transcription factor 1

E2243Ra

Sandwich

48T,96T

6.23ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).

48,556

50662

Acute myeloid leukemia 1 protein;Aml1;Cbfa2;CBF-alpha-2;Core-binding factor subunit alpha-2;Oncogene AML-1;PEA2-alpha;PEA2-alpha B;PEBP2-alpha;PEBP2-alpha B;Polyomavirus enhancer-binding protein 2 alpha B subunit;Runt-related transcription factor 1;RUNX1;

Runx1

Others

RUNX1