Steroid 17-alpha-hydroxylase/17,20 lyase

E2264Ra

Sandwich

48T,96T

7.75ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

57,250

25146

17-alpha-hydroxyprogesterone aldolase;Cyp17;CYP17A1;CYPXVII;Cytochrome P450 17A1;Cytochrome P450c17;Cytochrome P450-C17;Steroid 17-alpha-hydroxylase/17,20 lyase;Steroid 17-alpha-monooxygenase;

Cyp17a1

Cardiovascular

CYP17A1