Mitochondrial import inner membrane translocase subunit Tim8 A

E4311hu

Sandwich

48T,96T

9.56ng/L

20-3500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.

10,998

1678

DDP;DDP1;Deafness dystonia protein 1;DFN1;Mitochondrial import inner membrane translocase subunit Tim8 A;MTS;TIM8;TIMM8A;X-linked deafness dystonia protein;

TIMM8A

Signal Transduction

TIMM8A