C-type mannose receptor 2

E5136Hu

Sandwich

48T,96T

0.046ng/ml

0.1-40ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

166,674

9902

CD antigen CD280;CD280;CLEC13E;C-type lectin domain family 13 member E;C-type mannose receptor 2;ENDO180;Endocytic receptor 180;Macrophage mannose receptor 2;MRC2;UPARAP;UPAR-associated protein;Urokinase receptor-associated protein;Urokinase-type plasminogen activator receptor-associated protein;

MRC2

Cell Biology

MRC2