Gamma-aminobutyric acid receptor-associated protein-like 2

E5316Hu

Sandwich

48T,96T

0.046ng/mL

0.05-20ng/mL

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295).

13,667

11345

ATG8;ATG8C;GABA(A receptor-associated protein-like 2;GABARAPL2;Gamma-aminobutyric acid receptor-associated protein-like 2;Ganglioside expression factor 2;GATE16;GATE-16;GEF2;GEF-2;General protein transport factor p16;Golgi-associated ATPase enhancer of 16 kDa;MAP1 light chain 3-related protein;

GABARAPL2

Neuroscience

GABARAPL2