Glutamate--cysteine ligase catalytic subunit

E5338Hu

Sandwich

48T,96T

0.019ng/ml

0.05-20ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Glutamate—cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

72,766

2729

Gamma-ECS;Gamma-glutamylcysteine synthetase;GCL;GCLC;GCS;GCS heavy chain;GLCL;GLCLC;Glutamate--cysteine ligase catalytic subunit;

GCLC

Signal Transduction

GCLC