Interferon-induced protein with tetratricopeptide repeats 1

E5502Hu

Sandwich

48T,96T

5.16ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

55,360

3434

C56;G10P1;IFI56;IFI-56;IFI-56K;IFIT1;IFIT-1;IFNAI1;Interferon-induced 56 kDa protein;Interferon-induced protein with tetratricopeptide repeats 1;ISG56;P56;RNM561;

IFIT1

Others

IFIT1