NKG2-C type 2 integral membrane protein

E5778Hu

Sandwich

48T,96T

0.019ng/mL

0.05-20ng/mL

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674).

26,072

3822

CD antigen CD159c;CD159 antigen-like family member C;CD159c;KLRC2;NK cell receptor C;NKG2C;NKG2-C;NKG2-C type II integral membrane protein;NKG2-C-activating NK receptor;

KLRC2

Cancer

KLRC2