Phosphatidylinositide phosphatase SAC1

E5864Hu

Sandwich

48T,96T

5.37ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

128,407

22876

hSAC2;Inositol polyphosphate 5-phosphatase F;MSTP007;MSTPO47;Phosphatidylinositide phosphatase SAC2;Sac domain-containing inositol phosphatase 2;Sac domain-containing phosphoinositide 4-phosphatase 2;SAC2;SACM1L;

INPP5F

Signal Transduction

SACM1L