Phosphatidylinositol 3-kinase regulatory subunit beta

E5865Hu

Sandwich

48T,96T

6.96ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

81,545

5296

MPPH;MPPH1;p85;P85B;p85-BETA;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;Phosphatidylinositol 3-kinase regulatory subunit beta;PI3K regulatory subunit beta;PI3-kinase regulatory subunit beta;PI3-kinase subunit p85-beta;PIK3R2;PtdIns-3-kinase regulatory subunit beta;PtdIns-3-kinase regulatory subunit p85-beta;

PIK3R2

Signal Transduction; Immunology

PIK3R2