Insulin Like Growth Factor 2

E6283Ra

Sandwich

48T,96T

4.87ng/ml

8-1500ng/ml

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

20,086

24483

IGF-2;IGFII;IGF-II;Insulin-like growth factor II;MSA;Multiplication-stimulating activity;Multiplication-stimulating polypeptide;Preptin];RNIGF2;

Igf2

Signal Transduction; Cancer; Developmental Biology

IGF-2