Ubiquitin-associated and SH3 domain-containing protein A

E6375Hu

Sandwich

48T,96T

5.14ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

74,123

53347

Cbl-interacting protein 4;CLIP4;STS-2;Suppressor of T-cell receptor signaling 2;T-cell ubiquitin ligand 1;TULA;TULA-1;UBASH3A;Ubiquitin-associated and SH3 domain-containing protein A;

UBASH3A

Others

UBASH3A