B-cell antigen receptor complex-associated protein Alpha chain

E6672Hu

Sandwich

48T,96T

9.99ng/L

20-3800ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

25,038

973

B-cell antigen receptor complex-associated protein alpha chain;CD antigen CD79a;CD79A;IGA;Ig-alpha;MB-1;MB-1 membrane glycoprotein;Membrane-bound immunoglobulin-associated protein;Surface IgM-associated protein;

CD79A

Immunology; Cancer; Stem Cells

CD79A