Lysine-specific demethylase 3A

E6783Hu

Sandwich

48T,96T

3.48ng/L

7-1500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

147,341

55818

[histone H3]-dimethyl-L-lysine(9 demethylase 3A;JHDM2A;JHMD2A;JmjC domain-containing histone demethylation protein 2A;JMJD1;JMJD1A;Jumonji domain-containing protein 1A;Lysine-specific demethylase 3A;TSGA;

KDM3A

Neuroscience; Signal Transduction

JMJD1A