Prostaglandin E Synthase

E4229hu

Sandwich

48T,96T

7.57ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed: 18682561, PubMed: 10377395, PubMed: 12672824, PubMed: 12460774, PubMed: 10869354, PubMed: 12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed: 12244105, PubMed: 12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed: 12672824).

17,102

9536

Glutathione peroxidase PTGES;Glutathione transferase PTGES;MGST1-L1;Microsomal glutathione S-transferase 1-like 1;Microsomal prostaglandin E Synthase 1;MPGES-1;p53-induced gene 12 protein;Prostaglandin E Synthase;PTGES;

PTGES

Signal Transduction

PTGES