Interleukin Enhancer-Binding Factor 3

E5503Hu

Sandwich

48T,96T

4.84ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed: 28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed: 14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed: 21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed: 21123651, PubMed: 28625552).

95,338

3609

Double-stranded RNA-binding protein 76;DRBP76;ILF 3;ILF3;Interleukin enhancer-binding factor 3;M-phase phosphoprotein 4;MPP4;NFAR;NF-AT-90;Nuclear factor associated with dsRNA;Nuclear factor of activated T-cells 90 kDa;TCP80;Translational control protein 80;

ILF3

Signal Transduction

ILF3