Metastasis-Suppressor Kiss-1

E5666Hu

Sandwich

48T,96T

0.053ng/mL

0.1-40ng/mL

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated Peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

14,705

3814

KISS 1;KISS1;Kisspeptin-1;Kisspeptin-10;Kisspeptin-13;Kisspeptin-14;Kisspeptin-54;Metastasis-suppressor KiSS-1;Metastin;

KISS1

Neuroscience

KISS1