Polycystin-1

E5896Hu

Sandwich

48T,96T

8.96ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Component of a heteromeric calcium-permeable ion Channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed: 27214281). Both PKD1 and PKD2 are required for Channel activity (PubMed: 27214281). Involved in renal tubulogenesis (PubMed: 12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-Channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

462,529

5310

Autosomal dominant polycystic kidney disease 1 protein;PC1;PKD 1;PKD1;Polycystin-1

PKD1

Others

PKD1