Transcriptional Enhancer Factor TEF-1

E6297Hu

Sandwich

48T,96T

9.73ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

47,946

7003

NTEF-1;Protein GT-IIC;TCF-13;TEA domain family member 1;TEAD 1;TEAD1;TEAD-1;Transcription factor 13;Transcriptional enhancer factor TEF-1;

TEAD1

Others

TEAD1