A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5

E1580Mo

Sandwich

48T,96T

0.113ng/mL

0.2-70ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that shows proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed: 23233679). Participates in the development of brown adipose tissue and browning of white adipose tissue (PubMed: 28702327). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection (PubMed: 27855162).

101,844

23794

A disintegrin and metalloproteinase with thrombospondin motifs 5;ADAMTS 5;ADAM-TS 5;ADAMTS5;ADAMTS-5;ADAM-TS5;ADMP-2;Aggrecanase-2;Implantin;

ADAMTS5

Cell Biology

ADAMTS5