Stem Cell Factor/Mast Cell Growth Factor

E0135Hu

Sandwich

96T,48T

2.52pg/ml

5-1800pg/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

30,899

4254

c-Kit ligand;Kit ligand;KITLG;Mast cell growth factor;MGF;SCF;sKITLG;Soluble KIT ligand;Stem cell factor;

KITLG

Immunology

KITLG