T-Cell Surface Glycoprotein Cd4

E2507Mo

Sandwich

48T,96T

0.121ng/mL

0.2-70ng/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II Peptides are derived from extracellular proteins while class I Peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

51,297

12504

CD 4;CD antigen CD4;CD4;T-cell differentiation antigen L3T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4

CD4

Others

CD4