Disks Large Homolog 4

E1947Ra

Sandwich

48T,96T

9.88ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed: 15317815, PubMed: 15358863, PubMed: 19596852, PubMed: 23300088, PubMed: 26679993). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium Channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the Channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the Channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed: 19596852).

80,465

29495

Disks large homolog 4;DLG 4;DLG4;Postsynaptic density protein 95;PSD95;PSD-95;SAP90;SAP-90;Synapse-associated protein 90;

DLG4

Neuroscience

DLG4