Interleukin-12 subunit beta

E0171Sh

Sandwich

48T,96T

7.43ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Sheep

2-8ºC

1h 30m

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).

36,937

443472

CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12;IL-12 subunit p40;IL12B;IL-12B;Interleukin-12 subunit beta

IL12B

Immunology

IL12B