ATP Synthase subunit alpha, mitochondrial

E0530Po

Sandwich

48T,96T

9.52ng/L

20-3500ng/L

Serum, plasma, cell culture supernates

Porcine

2-8ºC

1h 30m

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).

59,688

100157880

ATP Synthase F1 subunit alpha;ATP Synthase subunit alpha heart isoform, mitochondrial;ATP Synthase subunit alpha liver isoform, mitochondrial;ATP Synthase subunit alpha, mitochondrial;ATP5A1;ATP5A2

ATP5F1A

Tags & Cell Markers; Signal Transduction; Metabolism

ATP5A1