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Home > Product > Antibody > MeCP2 Polyclonal Antibody

MeCP2 Polyclonal Antibody

MeCP2 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human

Applications: WB

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Applications: WB

Product overview

Full product name

Methyl-CpG-binding protein 2

Code

BT-AP11209

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

Synthetic Peptide of MeCP2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage

-20°C for 1 year

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

Uniprot accession

Gene ID

Human: 4204; Mouse: 17257; Rat: 29386

Synonyms

Methyl-CpG-binding protein 2; Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2

Research area

Epigenetics and nuclear signaling; Neuroscience

Target protein

MECP2

Recommended dilution

Application Dilution
WB 1: 2000

Images

Western blot analysis of Hela, diluted at1:2000;1:5000. Secondary antibody was diluted at 1:20000

Protocols

Customer reviews and Q&As

No reviews
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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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