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Home > Product > Antibody > CBP (Acetyl Lys1535) Polyclonal Antibody

CBP (Acetyl Lys1535) Polyclonal Antibody

CBP (Acetyl Lys1535) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IHC-p, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-p, ELISA

Product overview

Full product name

CBP (Acetyl Lys1535) Antibody

Code

BT-AP01266

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human CBP around the acetylated site of Lys1535. AA range:1501-1550

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), CREBBP is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREB binding protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREB binding protein acetylates both histone and non-histone proteins. CREB binding protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Uniprot accession

Molecular weight

265351

Gene ID

Human: 1387

Synonyms

CREBBP; CBP; CREB-binding protein

Research area

Epigenetics and Nuclear Signaling

Target protein

CREBBP

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IHC 1: 100 - 1: 300
ELISA 1: 20000

Images

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CBP (Acetyl-Lys1535) Antibody. The picture on the right is blocked with the synthesized peptide.
Western Blot analysis of various cells using Acetyl-CBP (K1535) Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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